US President Barack Obama has called for greater efforts to be made to reduce US and Russian nuclear arsenals.
He also called for reductions in the number of tactical warheads in Europe.
However Russia's Deputy Prime Minister Dmitry Rogozin said Moscow "cannot take these assurances seriously".
The US and Russian signed a joint agreement in 2010 to mutually reduce their stockpiles of nuclear weapons to a maximum of 1,550 warheads and no more than 700 deployed launchers.
Mr Obama said the US was "on track" to cutting its warheads to pre-Cold War levels, but "we have more work to do".
He said he had determined that the US could ensure its own and its allies security and maintain a credible deterrent "while reducing our deployed strategic nuclear weapons by up to one third".
"I intend to seek negotiated cuts with Russia to move beyond Cold War nuclear postures," he said.
"We may no longer live in fear of global annihilation but so long as nuclear weapons exist, we are not truly safe."
Mr Obama added that the US would also work alongside Nato allies to seek "bold reductions" in the use of tactical weapons in Europe, and would also seek to forge a new international framework for the use of peaceful nuclear power.
He also said the US rejected the nuclearisation of countries like North Korea and Iran.
But Mr Rogozin, a former Russian ambassador to Nato, said Moscow "cannot take these assurances seriously" while the US is taking steps to build up its missile defence systems.
"The offence arms race leads to a defence arms race and vice versa," he said in comments quoted in Russia's state-owned Itar-Tass
Shortly before Mr Obama spoke, Russian President Vladimir Putin was quoted as saying that Moscow "cannot allow the balance of the system of strategic deterrence to be disturbed or the effectiveness of our nuclear force to be decreased".
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